NovaDDE

Agentic intelligence for drug discovery.

NovaDDE is an AI-native platform for scientific reasoning and drug discovery. It connects frontier AI, scientific knowledge, specialized biological models, and computational tools into a unified agentic system built for complex scientific work.

How it works

From questions to scientific workflows.

Drug discovery rarely comes down to a single question. It requires reasoning across literature, biological evidence, molecular structures, computational models, and specialized tools.

NovaDDE brings these capabilities together in one environment, allowing scientists to move from a scientific question to analysis, computation, and actionable insight.

Ask complex scientific questions

Reason across biological mechanisms, disease hypotheses, targets, proteins, and therapeutic strategies.

Search and synthesize scientific knowledge

Navigate scientific literature and other sources of biological knowledge, connecting evidence across papers and disciplines.

Analyze proteins and molecular systems

Explore protein sequences, structures, interactions, mutations, and other molecular properties using specialized models and tools.

Orchestrate computational tools

NovaDDE can select and use specialized tools as part of a larger scientific workflow rather than treating each tool as an isolated endpoint.

Build multi-step workflows

Break complex scientific problems into steps, execute the appropriate analyses, interpret intermediate results, and continue reasoning toward an answer.

Architecture

Intelligence connected to tools.

NovaDDE brings together multiple layers of scientific intelligence:

Frontier AI

General reasoning, planning, synthesis, and scientific problem solving. You choose the provider your conversations run on.

GPTClaudeKimiQwen

Connect your own OpenAI, Anthropic or OpenRouter account, on a subscription or an API key.

Scientific Knowledge

Access to the literature and domain-specific biological information needed to ground scientific reasoning.

PubMedbioRxivUniProtKEGGChEMBLPDB

Eleven literature APIs including PMC full text, Europe PMC and Unpaywall, alongside 40+ bioinformatics services and 20+ gene and variant databases. Results carry reproducible provenance.

Specialized Models

Purpose-built AI models for biological and molecular problems, run on the deployment GPUs.

NovaAtomStructure prediction
RFdiffusion3Binder design
BioPhi (OASis)Antibody assessment
MolProbityStructure validation

BoltzGen, ESMFold and Protenix also run in the deployment catalog.

Scientific Tools

Computational methods and software that turn reasoning into quantitative analysis, as guided pipelines or as agent-driven jobs.

Peptide designAntibody designProtein binder designDockingMolecular dynamics

Twenty-four skills in this deployment, from cheminformatics and glycoengineering through to figure and manuscript preparation, connected over the Model Context Protocol so the tool layer extends without a release.

NovaDDE orchestrates these components dynamically based on the scientific problem at hand.

See NovaDDE in action

One question. A complete scientific workflow.

Start with a scientific objective. NovaDDE decomposes the problem, gathers relevant evidence, invokes specialized models and tools, analyzes the results, and builds toward an answer.

The result is not simply a response — it is a traceable scientific workflow.

Question Evidence Analysis Computation Insight
Use cases

Built for drug discovery.

NovaDDE is designed around the workflows that scientists encounter throughout therapeutic discovery. Potential applications include:

  • Target and disease biology research
  • Literature synthesis and hypothesis generation
  • Protein sequence and structure analysis
  • Protein interaction analysis
  • Therapeutic design exploration
  • Computational experiment planning
  • Scientific data interpretation
  • Multi-step research workflows
The goal is simple: reduce the distance between a scientific question and the evidence needed to act on it.
The Nova Stack

The reasoning layer of the stack.

NovaDDE is the reasoning and orchestration layer of Geodesic’s integrated AI and experimental platform.

NovaDDE reasons and orchestrates.
NovaAtom understands molecular structure and interactions.
NovaLab turns computational designs into experimental evidence.

Together, they create a closed learning loop:

Reason Predict Design Experiment Learn

NovaDDE connects intelligence across this stack, helping move scientific ideas from reasoning toward real-world experimentation.

From intelligence to medicines.

We are building NovaDDE to make increasingly powerful AI systems useful for the scientists working to understand biology and create new medicines.